Norovirus monoclonal antibodies

Norovirus is the leading non-bacterial cause of acute gastroenteritis in humans, responsible for at least 50% of all foodborne outbreaks worldwide. Outbreaks might be prevented or tracked by using broadly specific anti-norovirus antibodies to detect native virus particles in food or biological samples.

Commercially available and reliable anti-norovirus reagents are also greatly desired by scientists involved in norovirus research.

To meet these needs, Kim Laboratories has developed a panel of high affinity anti-norovirus monoclonal antibodies (mAbs), each one specific for a continuous capsid protein epitope common to a distinct group of genogroup I (GI) or genogroup II (GII) norovirus genotypes. Six mAbs have been generated to date, with two additional mAbs still in development. Because the targeted epitopes are naturally linear, our anti-norovirus mAbs are suitable for detecting denatured or native capsid proteins as well as whole intact virus particles.

Other anti-norovirus mAbs currently under development:

- Key epitope present on GII.6 capsid proteins.
- Key epitope present on GI.2, GI.4, GI.5 and GI.7 capsid proteins